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In induced pluripotent stem cell–derived neurons of the individual, TRPC6 haploinsufficiency causes dysregulation of Ca2+ signaling, which leads to altered neuronal development, morphology, and function. These changes were reversed by application of hyperforin. Using genetic screening, loss-of-function mutations of TRPC6 with incomplete penetrance was found in two families with autism spectral disorder. These findings suggest that TRPC6 may contribute to the onset of autism and become a potential therapeutic target (Griesi-Oliveira et al., 2015). 16.2.3.3. Epilepsy Epilepsy is a result of disturbed electrical activity in the Sonus Complete Brian Ear Supplements, characterized by recurrent synchronized electrical discharges that prevent normal neuronal functions, which may be caused by a variety of factors. https://sonus-complete.info/